Auxano® Technology

Discontinuous Surface Topology, Engineered for a Continuous Bony Interface

Benefits of Auxano®
The advancement of new concepts in hard tissue integration has been the goal of Auxano® since it was first introduced to the orthopedic space. As a platform technology, we hope to initiate a new perspective within the bone-implant interface across all implant varieties. Ultimately, this will contribute to the once distant aspiration within the orthopedic community involving personalized implant design, tailored to patient anatomy. Auxano® will also contribute to the progress that has been made in minimally invasive surgery (MIS), thus making procedures more streamlined with less hardware and simplified joint preparation. Auxano® Medical looks forward to being an innovative leader in orthopedics while also working with surgeons to ensure a safe and effective implementation. Through this evolution we will provide designs that translate into continuous fixation interfaces, efficient stress transfer, both primary & secondary fixation, fully engineered solutions, technology compatibility, as well as fabrication compatibility. To learn more about each of these contributing factors, please click the appropriately titled sections.

Continuous Fixation Interface

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Efficient Stress Transfer

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Primary & Secondary Fixation

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Fully Engineered Solution

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Technology Compatibility

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Fabrication Compatibility

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Continuous Fixation Interface

Negative features in porous implants require bone to grow along tortuous paths that are not interconnected, resulting in a discrete “discontinuous phase” of bone. Some porous surfaces have displayed incomplete bone migration to the base of the implant interface.

The positive pillar features of the Auxano® morphology take the role of the “discontinuous phase”, creating alleys for bone to interdigitate between. In this case, the growing bony interface forms an uninhibited “continuous phase” encapsulating the pillared structures.
Growing bone interdigitates within and around each pillar on the implant surface. Thus, the bone is the “continuous phase” enveloping the discrete pillared projections.
Efficient Stress Transfer

The order of magnitude difference in material properties between bone and metals used in orthopedic implants has plagued the industry for decades.

The Auxano® surface morphology provides a solution to this challenge by creating a structural transition zone where the stiffness of the pillar surface can be adjusted through manipulation of the pillar geometry and distribution. This allows the implant to gradually transition to the stiffness of the bone substrate.

The Auxano® technology allows greater control of the bone volume percent at the bone-implant interface by varying pillar spacing, size, length, and material characteristics.

Efficient Stress Transfer
Histology - Slide 19_Study I_1_ID 2718
Histology - Slide 20_Study I_2
Histology
Histology - Slide 152_Study II_2
CT Scan_PEEK_2
Primary & Secondary Fixation
Histology - Slide 19_Study I_1_ID 2718
Histology - Slide 20_Study I_2
Histology
Histology - Slide 152_Study II_2
CT Scan_PEEK_2
Primary & Secondary Fixation

Non-union, implant loosening, and implant infection are the top causes of failure in orthopedic devices. Primary and secondary fixation at the bone-implant interface is where these failed devices struggle to fulfill the desired outcome.

The Auxano® surface provides a high friction interface for initial implant stability. Once the interface is stable, bone migrates into the open matrix of pillars, eventually creating an interface that is more than 50% bone. Secondary fixation is achieved by maintaining a strain environment that sustains the long-term health and viability of the ingrown bone as shown in the histology image.
Initial motion control supplies the strain-limited environment necessary for new, primary bone formation. By maintaining intimate contact, the bone environment remains optimal and moves through its natural process of migration and wound healing. Studies to date show healthy osteon formation along the surface of the Auxano™ textured bulk implant with no indication of excessive inflammation or fibroplasia.
Fully Engineered Solution

Each location in the body brings about different local loading conditions and bone anatomy. There is a need to have control over the implant surface to account for the variability in these conditions.

The Auxano® morphology has a wide design space that is adaptable to the specific anatomical environment.
The ability to adjust array spacing, pillar geometry, and material characteristics are what give Auxano® the versatility to account for local loading conditions and bone anatomy.
Fully Engineered Solution
Technology Compatibility

Many surface technologies can only be applied on their own when an application may require a combination of surface morphologies to elicit the desired cellular response.

Since Auxano® is a macro surface morphology, it is compatible with micro and nano surface technologies and can combine the benefits provided by surfaces on multiple scales.
By existing on the 300-1000 µm scale, the Auxano® technology is able coexist with micro (1-300 µm) and nano (< 1 µm) scale surface technologies.
Fabrication Compatibility

A large percentage of the commonly used surface technologies are only compatible with certain substrate materials made using specific fabrication techniques.

The Auxano® surface morphology is made of the same substrate material as the implant, which opens it up to various additive and subtractive fabrication techniques. In an in-vivo study using an ovine model, multiple substrate materials were compared, and each demonstrated bone ingrowth viability using the Auxano® technology (https://doi.org/10.1016/j.jmbbm.2021.104775).
Being integral to the substrate material of the implant, there is the ability to fabricate the Auxano® morphology using the same fabrication technique as the overall implant. This also provides an innate shear strength to the surface and prevents any risk of delamination that is present when a coating or add-on process is applied to the surface.
Fabrication Compatibility

The Future of Osseointegration

 8006 Katherine Blvd, Brecksville, OH 44141

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